Formulation And Evaluation Of Sustained Release Tablet Of Tapentadol HCl

Hemangi PATEL *

Kalol Institute of Pharmacy, Kalol

Ashish Mahendrabhai Christian

N.R.Vekaria Institute Of Pharmacy, C.L. College Campus, Bilkha Road, Junagadh - 362001.


Aim of present research work was to “Formulation and evaluation of sustained release tablet of Tapentadol. The main reason for to sustain is because it has shorter half life and it gives effect only till 8 hours. Hydroxy Propyl Methyl Cellulose and ethyl cellulose were used as polymer to sustain the formulation. The different grades of HPMC and Ethyl cellulose polymer were used and with Yates method 8 different batches were prepared. Drug-excipients compatibility was studied by. FT-IR and Diff


Tapentadol HCl,HPMC, DSC, zero order kinetics