enAnalytical Method Development and Validation for Simultaneous Estimation of Lamotrigine and Valproate In Synthetic MixtureResearch ArticleLamotrigine (50 mg) and Sodium Valproate (250 mg) can be used in combination for the treatment of Seizure. Literature review reveals that this combination is not available. So it was thought of interest to generate idea about new combination which is much better than other formulation and also to develop and validate simple, accurate, sensitive and rapid RP-HPLC method for simultaneous estimation of both the drug in synthetic mixture. In RP-HPLC method, chromatographic separation was achieved onLamotrigine, Sodium Valproate, RP-HPLC, Validation.118 School of Pharmacy And Bio-Research Institute , Adalajyes Anil PValiyaabc@123.comMPharmacyShankersinh Vaghela Bapu Institute of Pharmacy, Vasan, Gandhinagarno