enDesign and Evaluation of Controlled Release Chitosan Microspheres of AceclofenacResearch ArticleIn the present investigation we developed novel controlled drug delivery of well-known NSAID Aceclofenac, which was successfully encapsulated into chitosan microspheres by single emulsion and chemical cross linking technique using glutaraldehyde. Prepared microspheres were subjected to FT-IR, SEM, studies. In the FT-IR spectrum of Aceclofenac (ACF) loaded chitosan microspheres does not shown any interaction between polymer and ACF. The size of microspheres of batch VI was positively influenced bNSAID, Microspheres1426 Kshirasagarnareshvcop@gmail.comMPharmacyVaagdevi College of Pharmacy, Ramnagar, Hanamkonda.yesSrilatha.Malveyabc@123.comOthersDivision of Pharmaceutics, Vaagdevi college of Pharmacy, Warangal-506001.noD.Adukondaluabc@123.comOthersDivision of Pharmaceutics, Vaagdevi college of Pharmacy, Warangal-506001noK .Senthilabc@123.comOthersDivision of Pharmaceutics Ultra College of pharmacy, Madurai- 625002no