EVALUATION OF ANTIEPILEPTIC ACTIVITY OF CALOTROPIS PROCERA LEAVES BY STRYCHNINE INDUCED TONIC CONVULSION IN MICE

Affiliation
Bhabani Shankar Nayak *

Institute of Pharmacy Technology, Salipur, Cuttack-754202, Odisha
CHANDRA SEKHAR BARIK

Institute of Pharmacy Technology, Salipur, Cuttack-754202, Odisha
SRUTI RANJAN MISHRA

Jeypore College of Pharmacy, Rondapalli, Jeypore – 764002, Koraput, Odisha.
Abstract

Background: Ethnobotanical and traditional study reveals that Calotropis procera is used extensively by the tribal people in eczema, leprosy, elephantiasis, rheumatism, epilepsy and diarrhea, jaundice and fever. Aim: The present study is an attempt to explore the antiepileptic activity of different leaf extracts of plant C. procera. Methodology: Various C. procera extracts were prepared using aqueous, ethanol, chloroform and petroleum ether as solvents. The extracts were screened for nontoxic pr

Keywords

Epilepsy, strychnine, convulsion, Soxhalation, C. procera.