Design and In Vitro Evaluation of Gastro Retentive Sustained Release Tablets of Ketorolac Tromethamine

Affiliation
Naresh Kshirasagar *

Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda.
P . Deepika

Natco Pharma Ltd., Kothur, Hyderabad.
Srilatha . Malvey

Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda.
D . Adukondalu

Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda.
Sriram . Pavani

Vaagdevi College of Pharmacy, Ramnagar, Hanamkonda.
Abstract

Gastro retentive sustained release tablets of ketorolac tromethamine (KT) were prepared by using hydrophilic polymers with direct compression on floating matrix technology and evaluated. KT is freely soluble in water, so it is suitable to develop it as gastro retentive sustained release tablets using hydrophilic polymers. The developed formulation is equivalent to calculated theoretical drug profile in view of its in vitro release. Technique has easily amenable to mass production using conventio

Keywords

Gastro retentive, ketorolac tromethamine, DSC, stability studies, zero-order, Fickian diffusion.